NMDA receptors

The NMDA receptor is a glutamate and ion channel protein receptor that is activated when glycine and glutamate bind to it. The receptor is a heteromeric complex that interacts with multiple intracellular proteins by three different subunits: GluN1, GluN2 and GluN3.

Project done in partnership with Teddy Grand and Pierre Paoletti, at the Institut de Biologie de l’École Normale Supérieure (IBENS). More information here.

GluN3A and GluN3B are glycine-binding subunits belonging to the NMDA receptor (NMDAR) family that can assemble with the GluN1 subunit to form unconventional receptors activated by glycine alone.
Teddy Grand et al.
Nat Commun. 2018 Nov 13 ;9(1):4769. doi : 10.1038/s41467-018-07236-4.